Resolution
scale and connections
Conventional cell profiling methods reveal vignettes - never the whole narrative
Functional assays and omics assays map distinct aspects of cells but are unable to reveal causal connections that can be therapeutically exploited. The next breakthroughs in life sciences will come from directly connecting molecular states of cells to their functional manifestation in complex environments.
Active-seq maps omics to cell function at unlimited scale
… revealing the full story of every cell.
Not only have we connected omics to live-cell function, the incorporated chemical perturbations enable simultaneous phenotypic and molecular screens for drug discovery through Active-Drug-seq.
Enabling techniques also define the future of high-throughput experimentation
The foundational platform allows performing 50,000-200,000 simultaneous experiments in nanoliter volumes, down to single cell resolution, compared to traditional 96-1536 well plate format.
A unique addressing mechanism allows every assay volume to be accessed individually in a single pipetting step. A single user can perform 10s of millions of experiments at their desk without expensive robotics.
The proprietary addressing mechanism also bridges physical space to sequence-space. Any sequencing based readout can connect longitudinal images of assay volumes to genomic content contained within.
Every cell in an assay volume can be tracked independently in imaging and sequencing space. Rather than be limited to single isolated cells we can study complex co-cultures at the single cell multi-omics resolution.
The implications of the scale, resolution and connections are transformative
We are pioneering a comprehensive experimental platform that brings scale, resolution and interconnectedness to biological and chemical data. Given the universality of the workflow, and the ease of execution, we are excited to point our abilities towards various cell types, perturbations and assay modalities. Our current efforts are directed to small molecule drug discovery and T cell analysis, with exploratory work in antibody-epitope mapping. The rapidity of insight generation and optimization allows us to advance a robust internal pipeline, as well.